Peer-reviewed Publications

Virus-based Cancer Immunotherapy Peer-reviewed Publications:

Int. J. Mol. Sci. 2019, 20, 621; doi:10.3390/ijms20030621

Int. J. Mol. Sci. 2019, 20, 621; doi:10.3390/ijms20030621

Kuryk
Optimization of Early Steps in Oncolytic Adenovirus. ONCOS-401 Production in T-175 and HYPERFlasks
ONCOIMMUNOLOGY https://doi.org/10.1080/2162402X.2018.1532763

ONCOIMMUNOLOGY https://doi.org/10.1080/2162402X.2018.1532763

Kuryk
Combination of immunogenic oncolytic adenovirus ONCOS-102 with anti-PD-1 pembrolizumab exhibits synergistic antitumor effect in humanized A2058 melanoma huNOG mouse model
J Med Virol. 2018;1–5. https://doi.org/10.1002/jmv.25229

J Med Virol. 2018;1–5. https://doi.org/10.1002/jmv.25229

Kuryk
Antitumor‐specific T‐cell responses induced by oncolytic adenovirus ONCOS‐102 (AdV5/3-D24-GM-CSF) in peritoneal mesothelioma mouse model
Cancer Gene Therapy https://doi.org/10.1038/s41417-018-0038-x

Cancer Gene Therapy https://doi.org/10.1038/s41417-018-0038-x

Kuryk
Quantification and functional evaluation of CD40L production from the adenovirus vector ONCOS-401
PLoS ONE 12(8): e0182715. https://doi.org/10.1371/journal.pone.0182715

PLoS ONE 12(8): e0182715. https://doi.org/10.1371/journal.pone.0182715

Kuryk
Toxicological and bio-distribution profile of a GM-CSF-expressing, double-targeted, chimeric oncolytic adenovirus ONCOS-102 - Support for clinical studies on advanced cancer treatment.
International Journal of Cancer 2016 Jun 10. doi: 10.1002/ijc.30228

International Journal of Cancer 2016 Jun 10. doi: 10.1002/ijc.30228

Kuryk
Synergistic anti-tumor efficacy of immunogenic adenovirus ONCOS-102 (Ad5/3-D24-GM-CSF) and standard of care chemotherapy in preclinical mesothelioma model
Journal for ImmunoTherapy of Cancer (Vol 4, Issue 17, 2016)

Journal for ImmunoTherapy of Cancer (Vol 4, Issue 17, 2016)

Ranki
Phase I study with ONCOS-102 for the treatment of solid tumors - an evaluation of clinical response and exploratory analyses of immune markers
Human Gene Therapy (Vol 26, Issue 8, 2015)

Human Gene Therapy (Vol 26, Issue 8, 2015)

Zamarin
Replication-competent viruses as cancer immunotherapeutics: emerging clinical data
OncoImmunology (Vol 4, Issue 7, 2015)

OncoImmunology (Vol 4, Issue 7, 2015)

Vassilev
Repeated intratumoral administration of ONCOS-102 leads to systemic antitumor CD8+ T-cell response and robust cellular and transcriptional immune activation at tumor site in a patient with ovarian cancer
OncoImmunology (Vol 3, Issue 10, 2014)

OncoImmunology (Vol 3, Issue 10, 2014)

Ranki
Local treatment of a pleural mesothelioma tumor with ONCOS-102 induces a systemic antitumor CD8+ T-cell response, prominent infiltration of CD8+ lymphocytes and Th1 type polarization